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aip (a selective inhibitor of camk ii  (GL Biochem)

 
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    Structured Review

    GL Biochem aip (a selective inhibitor of camk ii
    Changes <t>in</t> <t>CaMK</t> II expression after <t>AIP</t> intra-NAc administration. (A) p-CaMK II/t-CaMK II and GAPDH western blotting results of the saline control and AIP groups. (B) p-CaMK II/t-CaMK II ratios are displayed using histograms. The data in the experiment are expressed as the mean ± standard error of the mean. Two-tailed Student’s t -test was employed to assess the statistical difference among groups. Differences with * P < 0.05 are deemed statistically significant. CaMK II: calcium/calmodulin-dependent protein kinase, AIP: autocamtide-2-related inhibitory peptide, NAc: nucleus accumbens, p-CaMK II: phosphorylated CaMK II, t-CaMK II: total CaMK II, GAPDH: glyceraldehyde-3-phosphate dehydrogenase.
    Aip (A Selective Inhibitor Of Camk Ii, supplied by GL Biochem, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/aip+inhibitor/pmc10043793-28-22-29?v=GL+Biochem
    Average 90 stars, based on 1 article reviews
    aip (a selective inhibitor of camk ii - by Bioz Stars, 2026-07
    90/100 stars

    Images

    1) Product Images from "Calcium/calmodulin-dependent protein kinase II is involved in the transmission and regulation of nociception in naïve and morphine-tolerant rat nucleus accumbens"

    Article Title: Calcium/calmodulin-dependent protein kinase II is involved in the transmission and regulation of nociception in naïve and morphine-tolerant rat nucleus accumbens

    Journal: The Korean Journal of Pain

    doi: 10.3344/kjp.22372

    Changes in CaMK II expression after AIP intra-NAc administration. (A) p-CaMK II/t-CaMK II and GAPDH western blotting results of the saline control and AIP groups. (B) p-CaMK II/t-CaMK II ratios are displayed using histograms. The data in the experiment are expressed as the mean ± standard error of the mean. Two-tailed Student’s t -test was employed to assess the statistical difference among groups. Differences with * P < 0.05 are deemed statistically significant. CaMK II: calcium/calmodulin-dependent protein kinase, AIP: autocamtide-2-related inhibitory peptide, NAc: nucleus accumbens, p-CaMK II: phosphorylated CaMK II, t-CaMK II: total CaMK II, GAPDH: glyceraldehyde-3-phosphate dehydrogenase.
    Figure Legend Snippet: Changes in CaMK II expression after AIP intra-NAc administration. (A) p-CaMK II/t-CaMK II and GAPDH western blotting results of the saline control and AIP groups. (B) p-CaMK II/t-CaMK II ratios are displayed using histograms. The data in the experiment are expressed as the mean ± standard error of the mean. Two-tailed Student’s t -test was employed to assess the statistical difference among groups. Differences with * P < 0.05 are deemed statistically significant. CaMK II: calcium/calmodulin-dependent protein kinase, AIP: autocamtide-2-related inhibitory peptide, NAc: nucleus accumbens, p-CaMK II: phosphorylated CaMK II, t-CaMK II: total CaMK II, GAPDH: glyceraldehyde-3-phosphate dehydrogenase.

    Techniques Used: Expressing, Western Blot, Two Tailed Test



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    Changes <t>in</t> <t>CaMK</t> II expression after <t>AIP</t> intra-NAc administration. (A) p-CaMK II/t-CaMK II and GAPDH western blotting results of the saline control and AIP groups. (B) p-CaMK II/t-CaMK II ratios are displayed using histograms. The data in the experiment are expressed as the mean ± standard error of the mean. Two-tailed Student’s t -test was employed to assess the statistical difference among groups. Differences with * P < 0.05 are deemed statistically significant. CaMK II: calcium/calmodulin-dependent protein kinase, AIP: autocamtide-2-related inhibitory peptide, NAc: nucleus accumbens, p-CaMK II: phosphorylated CaMK II, t-CaMK II: total CaMK II, GAPDH: glyceraldehyde-3-phosphate dehydrogenase.
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    Changes <t>in</t> <t>CaMK</t> II expression after <t>AIP</t> intra-NAc administration. (A) p-CaMK II/t-CaMK II and GAPDH western blotting results of the saline control and AIP groups. (B) p-CaMK II/t-CaMK II ratios are displayed using histograms. The data in the experiment are expressed as the mean ± standard error of the mean. Two-tailed Student’s t -test was employed to assess the statistical difference among groups. Differences with * P < 0.05 are deemed statistically significant. CaMK II: calcium/calmodulin-dependent protein kinase, AIP: autocamtide-2-related inhibitory peptide, NAc: nucleus accumbens, p-CaMK II: phosphorylated CaMK II, t-CaMK II: total CaMK II, GAPDH: glyceraldehyde-3-phosphate dehydrogenase.
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    Changes <t>in</t> <t>CaMK</t> II expression after <t>AIP</t> intra-NAc administration. (A) p-CaMK II/t-CaMK II and GAPDH western blotting results of the saline control and AIP groups. (B) p-CaMK II/t-CaMK II ratios are displayed using histograms. The data in the experiment are expressed as the mean ± standard error of the mean. Two-tailed Student’s t -test was employed to assess the statistical difference among groups. Differences with * P < 0.05 are deemed statistically significant. CaMK II: calcium/calmodulin-dependent protein kinase, AIP: autocamtide-2-related inhibitory peptide, NAc: nucleus accumbens, p-CaMK II: phosphorylated CaMK II, t-CaMK II: total CaMK II, GAPDH: glyceraldehyde-3-phosphate dehydrogenase.
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    Image Search Results


    Changes in CaMK II expression after AIP intra-NAc administration. (A) p-CaMK II/t-CaMK II and GAPDH western blotting results of the saline control and AIP groups. (B) p-CaMK II/t-CaMK II ratios are displayed using histograms. The data in the experiment are expressed as the mean ± standard error of the mean. Two-tailed Student’s t -test was employed to assess the statistical difference among groups. Differences with * P < 0.05 are deemed statistically significant. CaMK II: calcium/calmodulin-dependent protein kinase, AIP: autocamtide-2-related inhibitory peptide, NAc: nucleus accumbens, p-CaMK II: phosphorylated CaMK II, t-CaMK II: total CaMK II, GAPDH: glyceraldehyde-3-phosphate dehydrogenase.

    Journal: The Korean Journal of Pain

    Article Title: Calcium/calmodulin-dependent protein kinase II is involved in the transmission and regulation of nociception in naïve and morphine-tolerant rat nucleus accumbens

    doi: 10.3344/kjp.22372

    Figure Lengend Snippet: Changes in CaMK II expression after AIP intra-NAc administration. (A) p-CaMK II/t-CaMK II and GAPDH western blotting results of the saline control and AIP groups. (B) p-CaMK II/t-CaMK II ratios are displayed using histograms. The data in the experiment are expressed as the mean ± standard error of the mean. Two-tailed Student’s t -test was employed to assess the statistical difference among groups. Differences with * P < 0.05 are deemed statistically significant. CaMK II: calcium/calmodulin-dependent protein kinase, AIP: autocamtide-2-related inhibitory peptide, NAc: nucleus accumbens, p-CaMK II: phosphorylated CaMK II, t-CaMK II: total CaMK II, GAPDH: glyceraldehyde-3-phosphate dehydrogenase.

    Article Snippet: The solutions for NAc microinjection were dissolved in 0.9% sterilized saline, and the drug concentration was 4, 8 or 12 µg of AIP (a selective inhibitor of CaMK II; GL Biochem) per milliliter.

    Techniques: Expressing, Western Blot, Two Tailed Test

    Neonatal rat cardiomoycytes were treated with 5μM AIP or vehicle starting 14h after the addition of 1μM Dox or medium (untreated). ( A ) Levels of cleaved caspase3 after 48h Dox treatment (n = 3–5). ( B ) Percentage of TUNEL positive cells in cells treated for 72h with Dox or medium in combination with AIP or vehicle. The ratio of DAPI positive and TUNEL positive nuclei was built. (n = 6). * P < 0.05 for matched 2-way ANOVA with Bonferroni post hoc testing. ( C ) Representative images of TUNEL positive (red) and negative cells. DAPI (blue) was used to stain nuclei. Scale bar represents 100 μm. ( D ) Number of cells positive for cleaved caspase9 after 48h treatment with Dox or ctrl in combination with AIP or vehicle (n = 5) ( E ) Representative images for caspase9 downregulation by AIP treatment. Scale bar represents 100 μm. ( F ) Apoptosis inducing factor (AIF) translocation: Relative signal intensity of anti-AIF antibody in the nucleus vs. cytosol after 48h Dox treatment (with and without AIP inhibition). All images except (B): p < 0.05, **p < 0.01 and ***p < 0.001 all for 1-way ANOVA with Bonferroni post hoc testing.

    Journal: PLoS ONE

    Article Title: CaMKII activation participates in doxorubicin cardiotoxicity and is attenuated by moderate GRP78 overexpression

    doi: 10.1371/journal.pone.0215992

    Figure Lengend Snippet: Neonatal rat cardiomoycytes were treated with 5μM AIP or vehicle starting 14h after the addition of 1μM Dox or medium (untreated). ( A ) Levels of cleaved caspase3 after 48h Dox treatment (n = 3–5). ( B ) Percentage of TUNEL positive cells in cells treated for 72h with Dox or medium in combination with AIP or vehicle. The ratio of DAPI positive and TUNEL positive nuclei was built. (n = 6). * P < 0.05 for matched 2-way ANOVA with Bonferroni post hoc testing. ( C ) Representative images of TUNEL positive (red) and negative cells. DAPI (blue) was used to stain nuclei. Scale bar represents 100 μm. ( D ) Number of cells positive for cleaved caspase9 after 48h treatment with Dox or ctrl in combination with AIP or vehicle (n = 5) ( E ) Representative images for caspase9 downregulation by AIP treatment. Scale bar represents 100 μm. ( F ) Apoptosis inducing factor (AIF) translocation: Relative signal intensity of anti-AIF antibody in the nucleus vs. cytosol after 48h Dox treatment (with and without AIP inhibition). All images except (B): p < 0.05, **p < 0.01 and ***p < 0.001 all for 1-way ANOVA with Bonferroni post hoc testing.

    Article Snippet: For specific CaMKII inhibition the CaMKII inhibitor myristoylated autocamtide-2-related inhibitory peptide (AIP) (Calbiochem/Merck/Millipore, Darmstadt, Germany) was used at a concentration of 5μM 14h after starting Dox treatment.

    Techniques: TUNEL Assay, Staining, Translocation Assay, Inhibition